The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer

The Remarkable Plasticity of Macrophages: A Chance to Fight Cancer

Blog Article

It is well established that tumor-associated macrophages (TAM) found in most advanced tumors have a pro-tumoral role.In this context, TAM limit the activity of tumor-infiltrating lymphocytes (TIL), and a number of mechanisms have been described including a trapping in the stroma, impeding TIL to reach malignant cells.Based on these results, a number of therapeutic approaches have been designed to deplete TAM.

However, during tumor regression induced by immunotherapeutic treatments, recent Wine Coolers studies revealed that TAM can switch from pro-tumoral to anti-tumoral and actively cooperate with TIL.Here, we will review the two faces of TAM in their interaction with TIL.We will summarize how they can inhibit T cell activities in growing tumors, and how they may also, together with T cells, successfully contribute to tumor eradication after Military Airplane Model Kit an appropriate stimulation.

Finally, we will discuss current promising therapies combining TAM reprogramming with T cell-based immunotherapy.